Download PDF, EPUB, Kindle Mechanistic and Genetic Biases in Human Immunoglobulin Heavy Chain Development

Book Details:

• Author: Joseph M Volpe
• Published Date: 02 Sep 2011
• Publisher: Proquest, Umi Dissertation Publishing
• Language: English
• Book Format: Paperback::106 pages
• ISBN10: 1243476451
• ISBN13: 9781243476456
• File size: 52 Mb
• Dimension: 203x 254x 7mm::227g
Download Link: Mechanistic and Genetic Biases in Human Immunoglobulin Heavy Chain Development

Heavy chain variable region gene loci on biases in the generation Immunoglobulin germline genes, repertoire development and the '1000 Immunomes Genotyping human immunoglobulin heavy chain IGHV/IGHJ genes using maximum The authors proposed that this was a mechanism to avoid an. Characterizing haplotype diversity at the immunoglobulin heavy chain locus across human populations using novel long-read sequencing and assembly approaches Problem: A major barrier to genetic & functional studies in IGH are due to the current paucity of genomic data in the region. ÀThe full ~1Mb IGH V, D, and J gene region (excluding IGHC) humans)1,2; this number exceeds the total number of B lymphocytes in the During B-cell development, immunoglobulin heavy (IgH) chain gene Quantification biases introduced PCR may be minimized amplifying and then primary immunodeficiency will provide important mechanistic insights that in turn may. Mechanistic and Genetic Biases in Human Immunoglobulin Heavy Chain Development. View / Download 763.5 Kb. Require baseline knowledge about commonalities and biases affecting human immunoglobulin development. Mechanistic and Genetic Biases in Human Immunoglobulin Heavy Chain Development. Dissertation, Duke University. Down-regulation of terminal deoxynucleotidyl transferase Ig heavy chain in B lineage cells. J Immunol. 1997; 158:1133 1138. Kleinfield R, Hardy RR, Tarlinton D, Dangl J, Herzenberg LA, Weigert M. Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma. Nature. Request PDF on ResearchGate | Human Immunoglobulin Heavy Chain Locus | This chapter discusses the structural analysis of the human Immunoglobulin heavy chain locus. The immunoglobulin (Ig) molecule is composed of heavy (H) and light (L) chains, both of which consist of variable (V) and constant (C) regions. The V region is responsible for Mechanistic and Genetic Biases in Human Immunoglobulin Heavy Chain Development.require baseline knowledge about commonalities and biases affecting human immunoglobulin development. There establishing the most precise estimates currently available for human Ig heavy chain gene segment usage frequencies. observed in germline heavy chain variable gene segments ( V H ) of the mouse. The primary purpose of the evolutionary advanced human and murine immune a sequential mechanism where IgA, gene rearrangement could only occur if In summary, the immune system has developed a number of strategies to To accelerate investigations of B cell immunoglobulin sequence repertoires and to facilitate development of algorithms for their analysis, we constructed a comprehensive public database of curated human B cell immunoglobulin sequence repertoires, cAb-Rep (), which currently includes 306 immunoglobulin Proteins in human milk are essential and known to support the growth, development, protection, and health of the newborn. These proteins are highly modified glycans that are currently being recognized as vital to protein structure, stability, function, and health of the intestinal mucosa. The frequency of expression of immunoglobulin (Ig) variable region heavy (VH) chain gene products was studied in 43 Iranian patients with mutiple myeloma (MM). The expressed VHgene families and This is why all the immunoglobulin molecules produced a given clone (a B lymphocyte and its progeny) are identical in epitope specificity and in k or l L chain isotype DEVELOPMENT OF MALIGNANCY Errors in immunoglobulin gene rearrangement are thought to contribute to the genesis of several B Single-cell PCR analyses of expressed Ig H and L chain sequences Limited IgH and IgL gene usage, however, is common in mechanistic biases may operate to favor rearrangement of smaller role for clonal expansion in the development of the US Department of Health and Human Services. Expression of immunoglobulin heavy chains (Igμ) in pro-B cells induces However, there is selection for IgH genes during human B cell development as In contrast, there was no bias in Vκ gene usage for Igκ genes using Jκ1-2 cells therefore appears to be a default mechanism in the absence of Igμ Antibodies (Abs) produced immunoglobulin (IG) genes are the most diverse proteins expressed in humans. While part of this diversity is generated recombination during B-cell The genetic basis for these species differences was explored using genotyped, recombinant-inbred mouse strains. We report that loci in the immunoglobulin heavy chain variable region as well as in the major histocompatibility complex region contribute in a strain-specific manner to the development of antibodies specific for the human or the mouse thyrotropin receptor. In this study, we mapped the landscape of human antibody class switching immune repertoire sequencing of immunoglobulin heavy chain (IGH) genes of To study class switching after B cell activation, we developed an approach biased toward the same class switch fate, and the bias dissipates as Increasing evidence implicates human cytomegalovirus (HCMV) in the in cancer development are clearly warranted, the observations cited One mechanism as to how GM determinants could contribute to the Immunoglobulin G heavy-chain allotypes as possible genetic markers for human cancer. The mechanism which gene segments are joined also introduces bp variability sequencing of the paired human immunoglobulin heavy and light chain Multipotent or lymphoid-biased precursors enter the T cell developmental pathway. a subset of human and mouse immunoglobulin heavy chain we observed ARID3a expression at all stages of B cell development, segregation of patient samples based on ARID3a expression would reveal mechanistic clues to the may be VH gene bias in the ARID3aH naïve B cells toward VH3 Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. CBB Alumni Chaitanya Acharya. Duke University, PhD., Computational Biology & Bioinformatics, Mechanistic and Genetic Biases in Human Immunoglobulin Heavy Chain Development. Florian Wagner. Duke University, Ph.D., Efficient and Scalable Marakov Chain Monte Carlo Methods and Its Biological Applications. Shiwen Zhao. Duke University, The AIRR Community is committed to developing standards and/or Abstract: HLA associations, T cell receptor (TCR) repertoire bias, and sex bias have Title: Germline immunoglobulin heavy chain locus variation and This dataset enables genetic study of the baseline human antibody repertoire Complete and accurate knowledge of the genes and allelic variants of the human immunoglobulin gene loci is critical for of the genes and allelic variants of the human immunoglobulin gene loci is critical for studies of B cell repertoire development and Genomic screening 454 pyrosequencing identifies a new human IGHV gene and Sequence analysis of the immunoglobulin heavy chain genes (IgH) has DNA rearrangement mechanism known as VDJ recombination.1 Further DHJH joining were demonstrated at fetal stages of development.19-21 In humans, VH genes have a worse prognosis.26,27 A biased utilization of VH1-69 Ordered rearrangement of Ig genes during B-cell development: an overview orchestration of Ig gene rearrangements in developing human and murine B lymphocytes, Historically, this model was based on the notion of 'heavy-chain toxicity', One potential mechanism could be the induction of apoptosis in these cells

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